Comparison of Cervical Cancer Screening Results Among 256,648 Women in Multiple Clinical Practices

In the United States, human papillomavirus (HPV) and Papanicolaou (Pap) testing (cotesting) for cervical screening in women ages 30 to 65 years is the preferred strategy, and cytology alone is acceptable. Recently, a proprietary automated test for identifying high-risk HPV types for primary cervical screening …

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Prediction of Outcome in Patients With Low-Grade Squamous Intraepithelial Lesions by Fluorescence In Situ Hybridization Analysis of Human Papillomavirus, TERC, and MYC

Cytology is an excellent method with which to diagnose preinvasive lesions of the uterine cervix, but it suffers from limited specificity for clinically significant lesions. Supplementary methods might predict the natural course of the detected lesions. The objective of the current study was to test whether a multicolor fluorescence in situ hybridization …

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The clinical impact of using p16INK4a immunochemistry in cervical histopathology and cytology: An update of recent developments

Cervical cancer screening test performance has been hampered by either lack of sensitivity of Pap cytology or lack of specificity of Human Papillomavirus (HPV) testing. This uncertainty can lead to unnecessary referral and treatment, which is disturbing for patients and increases costs for health care providers. The identification of p16INK4a as a marker …

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Biology and natural history of human papillomavirus infection

Human papillomavirus (HPV) is one of the most common causes of sexually transmitted diseases worldwide. It has been proposed that the great majority of women and men have been infected with HPV at least once during their lifetime. HPV infection is associated with a variety of clinical conditions, ranging from…

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GUIDANCE HPV Risk Stratification

P16 is associated with HPV induced dysplasia and malignant progression2 Ki-67 is associated with cell proliferation6 TERC gene amplification is associated with progression to CIN3 or invasive cervical cancer4 cMyc is the common site of HPV integration and is amplified in precancerous lesions…

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