POOLED ANTIBIOTIC
SUSCEPTIBILITY 
TESTING
(P-AST™)

 

P-AST™ BETTER REFLECTS THE INFECTION’S ACTUAL RESISTANCE IN THE BODY.

POLYMICROBIAL INFECTIONS ARE COMMON

More than half of positive UTI cases are polymicrobial.1

BACTERIAL INTERACTIONS IN POLYMICROBIAL SAMPLES CAN CHANGE SUSCEPTIBILITY

When there are multiple organisms present, pathogens may respond differently to antibiotics. Sometimes they are more susceptible, other times they are more resistant.2,3

Culture Sensitivity Testing

Pooled Antibiotic Susceptibility Testing
(P-AST™)

Testing on isolates doesn’t account for bacterial interactions.

Standard culture tests susceptibility on individual organisms, which doesn’t reflect what happens in the body with a polymicrobial infection. However, testing in a pooled environment, where organisms are grouped together, takes into consideration bacterial interactions.

P-AST™ IS PERSONALIZED

The presence of resistance genes does not necessarily translate into actual antibiotic resistance, and facility-wide antibiograms are not tailored to the specific strains in the individual patient. Our unique Pooled Antibiotic Susceptibility Testing (P-AST™) method evaluates 19 different antibiotics against the pool of organisms in the patient’s urine, providing a personalized result that accounts for bacterial interactions that may change antibiotic resistance.

Explore our tests that incorporate P-AST technology:

References:

  1. Vollstedt A, Baunoch D, Wojno KJ, Luke N, Cline K, et al. (2020). Multisite Prospective Comparison of Multiplex Polymerase Chain Reaction Testing with Urine Culture for Diagnosis of Urinary Tract Infections in Symptomatic Patients. J Sur urology, JSU-102. DOI: 10.29011/ JSU-102.100002
  2. Vollstedt A, Baunoch D, Wolfe A, Luke N, Wojno KJ, et al. (2020). Bacterial Interactions as Detected by Pooled Antibiotic Susceptibility Testing (P-AST) in Polymicrobial Urine Specimens. J Sur urology, JSU-101. DOI: 10.29011/JSU-101.100001
  3. Vos MG de, Zagorski M, McNally A, Bollenbach T (2017) Interaction networks, ecological stability, and collective antibiotic tolerance in polymicrobial infections. Proceedings of the National Academy of Sciences 114:10666–10671. https://doi.org/10.1073/pnas.1713372114