PERSONALIZED UTI THERAPY
RIGHT FROM THE START.

The only test that combines the sensitivity of PCR identification with a unique technology called Pooled Antibiotic Susceptibility Testing™ (P-AST™) to provide personalized urinary tract infection (UTI) therapy options.

 

GUIDANCE UTI IS AN ADVANCED TEST THAT PROVIDES SOLUTIONS TO COMMON CHALLENGES OF UTI DIAGNOSIS AND MANAGEMENT.

 

SOLUTION #1: Improved Sensitivity

 

Guidance® UTI has been shown to detect bacteria in 43% more cases than standard urine culture.1 The test uses PCR technology to identify uropathogens, including fastidious bacteria, yeast, and viruses that are difficult to detect by culture.

SOLUTION #2: Faster Results

 

Guidance® UTI provides results within 48 hours of receipt in the lab, while culture can take 3-5 days, reducing need for empiric therapy.2
 

SOLUTION #3: Identifies Polymicrobial Infections

Guidance® UTI’s identifies specific organisms and effective treatments for polymicrobial infections.  Polymicrobial infections are common, occurring in 53% of positive cases.1
 

SOLUTION #4: More Comprehensive

Guidance® UTI utilizes Pooled Antibiotic Susceptibility Testing™ (P-AST™), in addition to resistance gene testing, which provides personalized antibiotic options against the pool of organisms in the urine specimen. These results account for interactions that occur in polymicrobial infections that may alter antibiotic resistance.3
 

GUIDANCE UTI GIVES YOU MORE

Guidance UTI provides the sensitivity of PCR identification with resistance gene detection plus Pooled Antibiotic Susceptibility Testing™ (P-AST™).  This unique testing method evaluates antibiotics against the pool of organisms, allowing for personalized UTI therapy decisions.

WHAT IS POOLED ANTIBIOTIC SUSCEPTIBILITY TESTING (P-AST)?

P-AST better reflects the infection’s actual resistance in the body.

WHO NEEDS GUIDANCE UTI?

Patients who:
  • Have been diagnosed, or are suffering from symptoms of recurrent, persistent, or complicated UTI’s
  • Have been diagnosed with interstitial cystitis
  • Are male and experiencing prostatitis
High risk groups:
  • Pregnant
  • Elderly
  • Diabetic 
  • On chronic pain care regimens
  • Immunosuppressed
  • Men with UTIs
  • Past urinary culture results were “contaminated” or negative

VIEW A SAMPLE REPORT

The Guidance UTI report displays personalized therapy options to help speed the road to recovery.

My Patient’s UTI story

A video series dedicated to Urologists and the topic of urinary tract infections

What organisms does Guidance UTI test for?

In addition to the often-tested organisms Escherichia coli, Enterococcus faecalis, Klebsiella pneumoniae, and Staphylococcus aureus, we also test for an extremely comprehensive list of pathogens.

BACTERIAL/YEAST ORGANISMS:
  • Acinetobacter baumannii
  • Actinotignum schaalii
  • Aerococcus urinae
  • Alloscardovia omnicolens
  • Candida albicans
  • Candida auris
  • Candida glabrata
  • Candida parapsilosis
  • Citrobacter freundii
  • Citrobacter koseri
  • Corynebacterium riegelii
  • Enterococcus faecalis
  • Enterococcus faecium
  • Escherichia coli
  • Klebsiella oxytoca
  • Acinetobacter baumannii
  • Actinobaculum schaalii
  • Aerococcus urinae
  • Alloscardovia omnicolens
  • Candida albicans
  • Candida glabrata
  • Candida parapsilosis
  • Citrobacter freundii
  • Citrobacter koseri
  • Corynebacterium riegelii
  • Enterobacter aerogenes
  • Enterococcus faecalis
  • Escherichia coli
  • Klebsiella oxytoca
  • Klebsiella pneumoniae
  • Morganella morganii
  • Mycobacterium tuberculosis
  • Mycoplasma genitalium
  • Mycoplasma hominis
  • Pantoea agglomerans
  • Proteus mirabilis
  • Providencia stuartii
  • Pseudomonas aeruginosa
  • Serratia marcescens
  • Staphylococcus aureus
  • Streptococcus agalactiae
  • Streptococcus pyogenes
  • Ureaplasma urealyticum
BACTERIAL GROUPS:
  • Coagulase-neg. staphylococci*
  • Viridans group streptococci†
  • Enterobacter group‡
VIRAL PARTICLES:
  • BK virus
  • HHV-5 (CMV)
  • HHV-6
  • HHV-1, HHV-2 (HSV 1/2)
  • JC virus
  • Klebsiella pneumoniae
  • Morganella morganii
  • Mycobacterium tuberculosis
  • Mycoplasma hominis
  • Pantoea agglomerans
  • Proteus mirabilis
  • Providencia stuartii
  • Pseudomonas aeruginosa
  • Serratia marcescens
  • Staphylococcus aureus
  • Streptococcus agalactiae
  • Ureaplasma urealyticum
SEXUALLY TRANSMITTED ORGANISMS:
  • Chlamydia trachomatis
  • Neisseria gonorrhoeae
  • Trichomonas vaginalis
KEY
  • Guidance® UTI
  • Add-on tests

*Coagulase-neg. staphylococci: Staphylococcus epidermidis, Staphylococcus haemolyticus, Staphylococcus lugdunenesis, Staphylococcus saprophyticus

Viridans group streptococci: Streptococcus anginosus,
Streptococcus oralis, Streptococcus pasteuranus

‡Enterobacter group: Klebsiella aerogenes (formally known as Enterobacter aerogenes), Enterobacter cloacae

WHAT CLINICAL EVIDENCE SUPPORTS THE USE OF GUIDANCE UTI?

Guidance UTI has a large body of evidence, including three clinical studies with over 68,000 subjects and six peer-reviewed publications.

PEER-REVIEWED PUBLICATIONS

Key Findings and Clinical Implications

 

1. “Multiplex PCR Based Urinary Tract Infections (UTI) Analysis Compared to Traditional Urine Culture in Identifying Significant Pathogens in Symptomatic Patients”
  • PCR is 43% more sensitive than culture
  • M-PCR detected 93.4% of polymicrobial infections and culture only detected 22.3% of polymicrobial infections
  • Demonstrates that UTIs can be polymicrobial; culture is reported as “contaminated” if more than 2 organisms found

Read More

2. “Multisite Prospective Comparison of Multiplex Polymerase Chain Reaction Testing with Urine Culture for Diagnosis of Urinary Tract Infections in Symptomatic Patient”
  • Demonstrates that M-PCR has a greater ability to detect bacteria than culture
  • M-PCR detected 95% of polymicrobial Infections and culture only detected 22% of polymicrobial infections
  • More than half of positive UTI cases (53%) involve polymicrobial infections

Read More

3. “Bacterial Interactions as Detected by Pooled Antibiotic Susceptibility Testing (P-AST) in Polymicrobial Urine Specimens”
  • Bacterial interactions in polymicrobial specimens can alter susceptibility
  • Standard Antibiotic Susceptibility fails to detect the interaction
  • Pooled Antibiotic Susceptibility Testing captures interactions and provides more effective therapy options

Read More

4. “Utilization of M-PCR and P-AST for Diagnosis and Management of Urinary Tract Infections in Home-Based Primary Care”
  • Guidance UTI is associated with a 13.7% reduction in hospital utllization
  • Earlier studies have shown that 16.7% of patients presenting to emergency department with a UTI are admitted to the hospital for further management
  • > 1/2 of hospitalized Medicare patients develop UTl-related bacteremic episodes that lead to prolonged hospital stays with higher healthcare costs, or death

Read More

5. “After 180 Years, Is it time for Something Better for Diagnosing UTls?”
  • Novel advanced diagnostic testing methods such as M-PCR coupled with P-AST can provide clinically relevant microbiological data missed by SUC
  • M-PCR is able to quickJy detect relevant uropathogens, especially Gram-positive bacteria, along with more polymicrobial infections in patients with UTI symptoms
  • M-PCR/P-AST results are associated with better outcomes
  • data can offer valuable clinical information for antibiotic stewardship
6. “Concordance Between the Presence of Antibiotic Resistance Genes and Antibiotic Susceptibility Test Results in Symptomatic Patients with Urinary Tract Infection”
  • Overall, there was 60% concordance between presence/absence of ABR genes and pooled susceptlbility, while 40% of the time the data did not agree.
  • PCR alone to detect antibiotic resistance genes did not provide sufficient data in 40% of cases analyzed to make informed clinical decisions in UTI management.
  • However, when used in conjunction with P-AST. ABR gene data can offer valuable clinical information for antibiotic stewardship.

WHICH ANTIBIOTICS ARE INCLUDED IN GUIDANCE UTI’S POOLED ANTIBIOTIC SUSCEPTIBILTIY TESTING?

We leverage a dual assessment—genotype resistance and Pooled Antibiotic Susceptibility Testing (P-AST)—to uncover more effective, personalized therapy options.

Pooled Antibiotic Susceptibility Testing (P-AST) includes:
  • Ampicillin (PO/IV)
  • Ampicillin/Sulbactam (IV)
  • Amoxicillin/Clavulanate (PO)
  • Cefaclor (PO)
  • Cefazolin (IV)
  • Cefepime (IV)
  • Cefoxitin (IV)
  • Ceftazidime (IV)
  • Ceftriaxone (IM/IV)
  • Ciprofloxacin (PO/IV)
Genotype antibiotic resistance genes include:
  • Ampicillin
  • Carbapenem
  • Extended Spectrum Beta-Lactamase
  • Methicillin
  • Quinolinone/Fluoroquinolone
  • Vancomycin
  • Fosfomycin (PO/IV)
  • Gentamicin (IM/IV)
  • Levofloxacin (PO)
  • Meropenem (IV)
  • Nitrofurantoin (PO)
  • Piperacillin/Tazobactam (IV)
  • Sulfamethoxazole/Trimethoprim (PO/IV)
  • Tetracycline (PO)
  • Vancomycin (IV)
KEY
  • Guidance® UTI

WHICH RESISTANCE GENES DOES GUIDANCE UTI TEST?

Pathnostics’ GUIDANCE UTI Test utilizes PCR amplification for the targeted detection of agents. Pathogens are reported in ranges of organism(s) per milliliter of urine.

 

WHAT IS POOLED ANTIBIOTIC SUSCEPTIBILITY TESTING (P-AST)?

P-AST better reflects the infection’s actual resistance in the body.

GET GUIDANCE UTI NOW

Ready to provide your patients with personalized therapy right from the start?

By providing your contact information, you may be contacted by a member of Pathnostics regarding your request. Information collected using this form is stored on a third party server and then downloaded to Pathnostics. You further understand that any data provided to Pathnostics will be stored, used, and deleted consistent with Pathnostics’ Privacy Policy.
References

1. Vollstedt A, Baunoch D, Wojno KJ, Luke N, Cline K, et al. (2020). Multisite Prospective Comparison of Multiplex Polymerase Chain Reaction Testing with Urine Culture for Diagnosis of Urinary Tract Infections in Symptomatic Patients. J Sur urology, JSU-102. DOI: 10.29011/ JSU-102.100002
2. Macvane,Shawn & Neto, Lindsay & Nicolau,David. (2014). Demography and burden of care associated with patients readmitted for urinary tract infection. Journal of Microbiology, Immunology and Infection. 48. 10.1016/j.jmii.2014.04.002.
3. Vollstedt A, Baunoch D, Wolfe A, Luke N, Wojno KJ, et al. (2020) Bacterial Interactions as Detected by Pooled Antibiotic Susceptibility Testing (P-AST) in Polymicrobial Urine Specimens. J Sur urology: JSU-101. DOI: 10.29011/JSU-101.100001